Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Educating young people about how to interact with patients at the end of their lives is challenging. A qualitative study based on Husserl’s phenomenological approach was performed to describe the learning experience of secondary education students after watching, analysing, and reflecting on two videoclips featuring Cameron Duncan, a young man suffering from terminal cancer. Students from three vocational centres providing training in ancillary nursing, pharmacy, and dependent care in the Community of Madrid visited the Palliative Care Hospital. A total of (...) 110 students, with a median age of nineteen years, participated in the study. The students’ learning experience through the videoclips reveals the essential aspects required in palliative care, since the character suffers in every dimension of his being: physically as well as psychologically, socially, and spiritually. Therefore, this requires healthcare professionals to understand their experience, putting themselves in their place, to provide affectionate care and to display communication skills leading to a quality helping relationship. Four comprehensive educational categories were identified in the study. The students learned the importance of: 1) providing comprehensive and affectionate care to patients, 2) the need for communication skills in caring for patients, 3) being aware of the end of life and time left, 4) valuing life and fighting for what one wishes to attain. A visit to a PC hospital and the viewing of videoclips and reflection upon these, represents a useful strategy for secondary education healthcare students. The study indicates that videoclips are an innovative method for becoming aware of the various issues pertaining to palliative care. (shrink)

BackgroundBased on an actual case in which a psychiatrist was called in to assess a patient’s capacity to refuse treatment, the aim of this study is to discuss how to manage this ethical and clinical issue and the dilemmas faced by the medical team.Case presentation: The case involved a 45-year-old female patient diagnosed with breast cancer who refused treatment. Since the mastology team had doubts about the patient’s mental state and given that she refused to consent to surgery, a forensic (...) psychiatric consult was requested.ConclusionThe forensic psychiatry team concluded that the patient’s decision-making capacity was preserved. The team suggested some actions to help the specialists deal with the ethical conflict. A reflection is proposed about the role of psychiatrists when an ethical dilemma involving decision-making capacity emerges in clinical situations, elucidating their work not only as physicians who determine diagnoses and conducts, but also as agents of transformation in the doctor–patient re... (shrink)

A bibliometric index is proposed that accounts for the differential contribution authors make to a joint paper published, the valuation of the number of publications, the quality of the journals in which the authors are published and which cite them, as well as the timeliness of the paper. This approach means the index can be used in selection processes for positions of employment or the award of research projects, as it abides by the premise of considering scientific merit based on (...) the quality and quantity of publications. The term weighted citability index is used to refer to a mathematical process that uses filters proportionally both to the degree of involvement in the joint research and to the values of number, quality, and timeliness of the research papers. (shrink)

Natural deduction systems for classical, intuitionistic and modal logics were deeply investigated by Prawitz [D. Prawitz, Natural Deduction: A Proof-theoretical Study, in: Stockholm Studies in Philosophy, vol. 3, Almqvist and Wiksell, Stockholm, 1965. Reprinted at: Dover Publications, Dover Books on Mathematics, 2006] from a proof-theoretical perspective. Prawitz proved weak normalization for classical logic only for a language without logical or, there exists and with a restricted application of reduction ad absurdum. Reduction steps related to logical or, there exists and classical (...) negation bring about many problems solved only rather recently. For classical S5 modal logic, Prawitz defined a normalizable system, but for a language without logical or, there exists, ◊ and, for a propositional language without ◊, Medeiros [M.da P.N. Medeiros, A new S4 classical modal logic in natural deduction, Journal of Symbolic Logic 71 799–809] presented a normalizable system for classical S4. We can mention many cut-free Gentzen systems for S4, S5 and K45/K45D, some normalizable natural deduction systems for intuitionistic modal logics and one more for full classical S4, but not for full classical S5. Here our focus is on the definition of a classical and normalizable natural deduction system for S5, taking not only □ and ◊ as primitive symbols, but also all connectives and quantifiers, including classical negation, disjunction and the existential quantifier. The normalization procedure is based on the strategy proposed by Massi [C.D.B. Massi, Provas de normalizaçaõ para a lógica clássica, Ph.D. Thesis, Departamento de Filosofia, UNICAMP, Campinas, 1990] and Pereira and Massi [L.C. Pereira, C.D.B. Massi, Normalização para a lógica clássica, in: O que nos faz pensar, Cadernos de Filosofia da PUC-RJ, vol. 2, 1990, pp. 49–53] for first-order classical logic to cope with the combined use of classical negation, disjunction and the existential quantifier. Here we extend such results to deal with □ and ◊ too. The elimination rule for ◊ uses the notions of connection and of essentially modal formulas already proposed by Prawitz for the introduction of □. Beyond weak normalization, we also prove the subformula property for full S5. (shrink)

INDICE -/- Note biografiche Introduzione, di Riccardo Faucci -/- Parte I - Da Verri a Toniolo 1. Jeremy Bentham: Contemporary Interpretations, di M.D.A. Freeman 2. Su Helvétius, Beccaria e Bentham, di Letizia Gianformaggio 3. L'etica utilitaristica di Pietro Veti, di Vincenzo Polignano 4. ll liberismo interventista di Vincenzo Emanuele Sergio, di Anna Li Donni 5. Il concetto di " felicità pubblica, nella << Genesi del diritto penale » di Romagnosi, e il rapporto Romagnosi-Bentham, di Robertino Ghiringhelli 6. « La più (...) grande felicità per il maggior numero » all'Accademia dei Georgofili ( 18)0-1850), di Gabriella Gioli 7. Una nota su Manzoni critico dell'utilitarismo, di Maurizio Mori 8. Sul concetto di utile in Francesco Ferrara e in Maffeo Pantaleoni, di Daniela Parisi Acquaviva 9. Sul pensiero sociale cristiano di fronte all'edonismo, di Luciano Avagliano 10. Giuseppe Toniolo e il recupero cattolico dell'utile e del valore, di Anna Camaiti -/- Parte II Aspetti di storia del pensiero economico nell’età classica -/- 1. La filosofia economica di Thomas Hobbes, di Marco Bertozzi 2. Ordinamento del sapere, modelli metodologici ed economia politica in Adam Smith, di Sergio Cremaschi 3. Elementi classici nel pensiero di Adam Smith: giurisprudenza romana e morale stoica, di Gloria Vivenza 4. Il “lusso” negli economisti italiani del Settecento, di Cosimo Perrotta 5. Prezzi naturali, prezzi di mercato e legge degli sbocchi nel dibattito fra Malthus e Ricardo, di Lilia Costabile 6. Marx e la moneta, di Roberto Petrini -/- . (shrink)

This article evaluated the effects of an interpersonal skills program based on artistic expressions to reduce intimate partner violence in college students. The research was of explanatory type, quasi-experimental design and used the Dating Abuse questionnaire (adapted by Osorio, 2014), the Interpersonal Skills questionnaire with reliability of 0.81 having as results in the entry test in terms of violence a mean of 88. 16 and after the program was applied it decreased to 81.2, in interpersonal skills the mean of 46.6 (...) increased to 53.3 with large effect size according to Cohen's d 7.889 CI95% (6.246-9.532), statistically significant differences were found in terms of violence. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

The humanitarian sector continually faces organizational and operational challenges to respond to the needs of populations affected by war, disaster, displacement, and health emergencies. With the goal of improving the effectiveness and efficiency of response efforts, humanitarian innovation initiatives seek to develop, test, and scale a variety of novel and adapted practices, products, and systems. The innovation process raises important ethical considerations, such as appropriately engaging crisis-affected populations in defining problems and identifying potential solutions, mitigating risks, ensuring accountability, sharing benefits (...) fairly, and managing expectations. This paper aims to contribute to knowledge and practice regarding humanitarian innovation ethics and presents two components related to a value-sensitive approach to humanitarian innovation. First is a mapping of how ethical concepts are mobilized in values statements that have been produced by a diverse set of organizations involved in humanitarian innovation. Analyzing these documents, we identified six primary values (do-no-harm, autonomy, justice, accountability, sustainability, and inclusivity) around which we grouped 12 secondary values and 10 associated concepts. Second are two proposed activities that teams engaged in humanitarian innovation can employ to foreground values as they develop and refine their project’s design, and to anticipate and plan for challenges in enacting these values across the phases of their project. A deliberate and tangible approach to engaging with values within humanitarian innovation design can help to ground humanitarian innovation in ethical commitments by increasing shared understanding amongst team members, promoting attentiveness to values across the stages of innovation, and fostering capacities to anticipate and respond to ethically challenging situations. (shrink)

Mediante el análisis de las relaciones de parentalidad en Tiempo de vida, El cuerpo en que nací y ¿Por qué ser feliz cuando puedes ser normal?, de Marcos Giralt Torrente, Guadalupe Nettel y Jeanette Winterson respectivamente, se expondrá cómo la literatura autoficcional, en tanto ejercicio artístico, adquiere también una función capaz de reconfigurar la realidad patriarcal y, así, contribuir a desmontar un esencialismo estructural. La incipiente actualidad de estos autores constituye también una propuesta de escrituras descentralizadas o marginales leídas desde (...) el Sur: literatura de los hijos parentales, literatura de mujeres y literatura con perspectiva homoerótica. Para ello, partiendo de una metodología comparatista literaria desde epistemologías de género del Sur, se ejemplifican y visibilizan costumbres heteronormativas de un contexto capitalista que deteriora la identidad de un yo relacional, en un sistema político, social y económico jerárquico y represor. Se realiza un análisis de personajes que rompen con la idea estereotípica de relaciones familiares, permitiendo así esbozar nuevas concepciones de identidad a partir de una serie de autores clave en el tema de la ruptura heteronormativa. La presente es una apuesta en favor de la literatura como un arte que, además de brindar goce estético, puede constituir una poderosa vía de concientización y transformación epistémica –es decir, del desplazamiento del deseo–, a partir de la experiencia humana, en general y, en particular, a través de la experiencialidad ficcional (cargada de tintes autobiográficos) de un yo-relacional que da cuenta de vicisitudes relacionadas con el mandato de masculinidad, entendido como “la obligación de dominio que recae sobre los hombres” de algunos personajes literarios. Tal obligación [y la] “investidura [social que se impone] a quienes cargan un cuerpo masculino” son cuestionadas e incluso transformadas en los textos seleccionados que, cuando son explorados en el marco de la educación superior, pueden contribuir a la educación inclusiva en el Sur global. (shrink)

ResumoO objetivo deste artigo é produzir uma reflexão crítica sobre a produção de Gilberto Freyre, mais verticalizada em dois aspectos. Em primeiro lugar, buscar-se-á entender a seleção feita por esse antropólogo de uma certa mestiçagem e adaptação cultural, símbolos da singularidade brasileira. Em segundo lugar, procura-se entender de que maneira esse tipo de interpretação desloca a análise de fenômenos mais sociais e econômicos, investindo profundamente na esfera privada. Como se costuma dizer, Freyre teria descrito a escravidão brasileira, tendo como foco (...) apenas os cativos domésticos. Para tanto, começar-se-á com a análise do clássico Casa Grande & Senzala, mas a insistência se dará na interpretação do livro Novo mundo nos trópicos, obra em que o estudioso procura sintetizar suas conclusões para um público estrangeiro. Aí estariam condensadas as suas máximas e grandes linhas de interpretação.Palavras-chave: Adaptação. Mestiçagem. Novo mundo nos trópicos. Gilberto Freyre. AbstractThe aim of this paper is to produce a critical reflection on Gilberto Freyre’s work, which is more vertical in two respects. First, I will seek to understand the selection made by the anthropologist of a certain cultural miscegenation and adaptation, symbols of Brazilian singularity. Second, I’ll try to understand how such an interpretation shifts the analysis of rather social and economic phenomena, deeply invested in the private. As it is said, Freyre would have described Brazilian slavery focusing only on the domestic slaves. Thus, the analysis begins with the classic Casa Grande & Senzala, but the emphasis will be in the interpretation of the book in the New world in the tropics [Novo mundo nos Trópicos], a work in which the scholar seeks to synthesize his findings to a foreign audience. There it would be condensed his maxima and broad lines of interpretation.Key words: Adaptation. Miscegenation. New world in the tropics. Gilberto Freyre. (shrink)

The article offers an account of the author's participation in secret filming in three small residential care homes for older people. The author gained access to the homes as a resident and made video-recordings that were used as part of a television documentary in 1994 that exposed the poor practice and lack of regulation in these types of homes in England at that time. The author discusses her motivations for taking on this undercover role, and some of the unexpected ethical (...) challenges she faced when considering the impact of the exposure of these homes for the residents, their families, the owners and the staff. (shrink)

The aging of the population presents modern Western society with a variety of different challenges, especially in the areas of health and medicine. On the one hand, there is the demand of the elderly patients to receive medical treatments that are supposed to improve or preserve the existing quality of life and to prevent the extension of a life without quality, with suffering and pain. On the other hand, aging is accompanied by the appearance and exacerbation of chronic illnesses, reduces (...) the treatment benefits of medical activities and increases the risks of irreversible physical dependence. Furthermore, the lack of consensus among the physicians regarding the willingness of treatment and the proper timing of the treatment of the elderly – pose questions about the quality of the treatment for the elderly. Thus, in the opinion of different care-providers and in comparison to other age groups in modern Western society, the elderly do not enjoy the treatment advantages of medical activities proven in the treatment of other age groups in society. (shrink)

Cognitive Science, Volume 46, Issue 5, May 2022.

At conceptual and linguistic levels of cognition, events are said to be represented in terms of abstract categories, for example, the sentence Jackie cut the bagel with a knife encodes the categories Agent (i.e., Jackie) and Patient (i.e., the bagel). In this paper, we ask whether entities such as the knife are also represented in terms of such a category (often labeled “Instrument”) and, if so, whether this category has a prototype structure. We hypothesized the Proto-instrument is a tool: a (...) physical object manipulated by an intentional agent to affect a change in another individual or object. To test this, we asked speakers of English, Dutch, and German to complete an event description task and a sentence acceptability judgment task in which events were viewed with more or less prototypical instruments. We found broad similarities in how English, Dutch, and German partition the semantic space of instrumental events, suggesting there is a shared concept of the Instrument category. However, there was no evidence to support the specific hypothesis that tools are the core of the Instrument category—instead, our results suggest the most prototypical Instrument is the direct extension of an intentional agent. This paper supports theoretical frameworks where thematic roles are analyzed in terms of prototypes and suggests new avenues of research on how instrumental category structure differs across linguistic and conceptual domains. (shrink)

This article is the analysis of the content of the Ukrainian periodicals for womenfolk, including the literary-publicistic almanac "Pershyi vinok", the periodical "Meta", the newspaper "Zhinoche dilo" which was a free supplement to the daily social and political narodovskyi publication "Dilo". They were published with the support of the public organizations of Galicia in late 19th and early 20th century and of the activists of the Ukrainian women's movement of the region - Nataliia Kobrynska, Olena Kysilevska, Dariia Starosolska, Iryna Sichynska (...) and others. These periodical and non-periodical publications familiarized Ukrainian women with the best works of Foreign and Ukrainian literature, highlighted the women's movement and the events of political life both in Austria-Hungary and abroad, as well as various aspects of the activities of public organizations where women were involved, published a lot of useful information etc. We believe that the almanac "Pershyi vinok", the newspapers "Meta", "Zhinoche dilo" contributed not only to raising cultural and educational levels of women and spreading among them the ideas of gender equality, but also are valuable sources for the study of the Ukrainian national and cultural movement of Galicia in late 19th and early 20th century. They contain quite a few important facts necessary for a researcher to reconstruct the events of national and cultural life in the region during the above-mentioned period of time. However, a relatively short period of publishing of the said periodicals does not make it possible to get a coherent picture of the Ukrainian women's movement as one of the important components of the national and cultural movement in Galicia in late 19th and early 20th century, thus requiring additional study of both archival and other published sources. (shrink)

One of the most lively debates on scientific understanding is standardly presented as a controversy between the so-called factivists, who argue that understanding implies truth, and the non-factivists whose position is that truth is neither necessary nor sufficient for understanding. A closer look at the debate, however, reveals that the borderline between factivism and non-factivism is not as clear-cut as it looks at first glance. Some of those who claim to be quasi-factivists come suspiciously close to the position of their (...) opponents, the non-factivist, from whom they pretend to differ. The non-factivist, in turn, acknowledges that some sort of ‘answering to the facts’ is indispensable for understanding. This paper discusses an example of convergence of the initially rival positions in the debate on understanding and truth: the use of the same substitute for truth by the quasi-factivist Kareem Khalifa and the non-factivists Henk de Regt and Victor Gijsbers. It is argued that the use of ‘effectiveness’ as a substitute for truth by both parties is not an occasional coincidence of terms, it rather speaks about a deeper similarity which have important implications for understanding the essential features of scientific understanding. (shrink)

In a series of recent publications Jerry Fodor has attacked what many believe is the core of Darwinian theory of evolution – the theory of natural selection. Not surprisingly, Fodor’s attack has provoked a strong negative reaction. Fodor’s critics have insisted both that his main argument is unsound and that his central claim that the theory of natural selection “can’t explain the distribution of phenotypic traits in biological populations” is untenable. I can generally agree with the first part of the (...) launched criticism: Fodor’s “putative argument” does rely on controversial premises which make it unsound. However, I don’t think that Fodor’s critics have succeeded in their attempts to refute his central claim. The refutation strategy that most of them have undertaken is to show examples of successful evolutionary explanations by natural selection. In what follows, two of these examples are put into scrutiny. The analysis reveals that: (1) The theory of natural selection should be only partially credited with the explanatory success of evolutionary explanations by natural selection because these explanations rely on additional empirical hypotheses which might be true or false. That means that the selectionist explanations are fallible statements the truth value of which depends crucially on the truth value of the empirical assumptions which have been premised. (2) In both cases alternative non-selectionist explanations can be found that fit the same empirical data and no reason has been given (or could be given) why these alternative explanations should be ignored a priori as inferior. The observations (1) and (2) stand against the claim that theory of natural selection is the only legitimate explanance for the distribution of phenotypic traits. This does not mean, of course, that natural selection does not play any explanatory role or that the theory of natural selection is a false theory (as Fodor is inclined to argue for). This only means that there is indeed a problem of understanding the proper explanatory role of natural selection and that this problem is not only Fodor’s problem. The paper ends with a suggestion of what should be admitted in order to get to a better understanding of the proper role that the theory of natural selection plays in evolutionary explanations. (shrink)

The central argument in this paper is the following: if we agree that one of the aims of explanation is to provide or increase understanding, and if we assess understanding on the basis of the inferences one can draw from the knowledge of the phenomenon which is understood, then the value of an explanation, i.e. its capacity to provide or increase understanding of the explained phenomenon, should be assessed on the basis of the extra-inferences which this explanation allows for. The (...) extra-inferences which a given explanation allows for constitute its inferential content. The analysis of the explanation’s inferential content could be applied to all kinds of explanations with the aim of assessing their goodness. I show how such an analysis helps us to better understand a number of difficulties that have puzzled contemporary philosophers of explanation: the flagpole counterexample to the deductive-nomological model of explanation, the conjunction problem, the difference between good and bad circular explanations. (shrink)

On observe une nouvelle tendance dans la philosophie des sciences cognitives, manifeste dans les écrits de Betchel et al. qui met en avant l’importance des explications mécanistes au détriment du rôle explicatif des principes. Cet article est un plaidoyer pour rétablir l’équilibre. Il met l’accent sur l’effort d’explication des effets du niveau de base, l’une des plus importantes découvertes empiriques dans l’histoire de la recherche en catégorisation. L’analyse de trois différentes périodes de cette histoire révèle que le recours aux principes (...) y a joué un rôle crucial. Cependant, afin de reconnaître pleinement le rôle explicatif des principes, nous devrions nous préparer à admettre que les explications déductives-nomologiques ne sont pas les seuls types d’explications basées sur des principes. (shrink)

On observe une nouvelle tendance dans la philosophie des sciences cognitives, manifeste dans les écrits de Betchel et al. qui met en avant l’importance des explications mécanistes au détriment du rôle explicatif des principes. Cet article est un plaidoyer pour rétablir l’équilibre. Il met l’accent sur l’effort d’explication des effets du niveau de base, l’une des plus importantes découvertes empiriques dans l’histoire de la recherche en catégorisation. L’analyse de trois différentes périodes de cette histoire révèle que le recours aux principes (...) y a joué un rôle crucial. Cependant, afin de reconnaître pleinement le rôle explicatif des principes, nous devrions nous préparer à admettre que les explications déductives-nomologiques ne sont pas les seuls types d’explications basées sur des principes. (shrink)

This paper is an update of the documents we have concerning the Acts of the Christian martyrs, focused on three main aspects: 1) the kind of acts we know of and their classification from the point of view of their historic value; 2) the versions or editions of the texts that are most accepted by scholars; 3) the relevance of the different parts that make up these documents in order to discern the original text from passages that were rewritten or (...) underwent later variations. In this way, the article offers an exhaustive list of the documents for use in researching Christian martyrs in the Roman period. (shrink)

In recent literature, panpsychism has been defended by appeal to two main arguments: first, an argument from philosophy of mind, according to which panpsychism is the only view which successfully integrates consciousness into the physical world (Strawson 2006; Chalmers 2013); second, an argument from categorical properties, according to which panpsychism offers the only positive account of the categorical or intrinsic nature of physical reality (Seager 2006; Adams 2007; Alter and Nagasawa 2012). Historically, however, panpsychism has also been defended by appeal (...) to a third argument based on considerations about the nature and observability of causation. This argument has not been much discussed in recent times. Here is a concise version from William James: "… the concrete perceptual flux, taken just as it comes, offers in our own activity-situations perfectly comprehensible instances of causal agency … If we took these experiences as the type of what actual causation is, we should have to ascribe to cases of causation outside of our life, to physical cases also, an inwardly experiential nature. In other words, we should have to espouse a so-called “pan-psychic” philosophy" (James 1911: 218). James here suggests that we have direct experience of causation in our own agency. He thereby directly contradicts David Hume, who famously denied that we have any experience of causation. James goes on to claim that if this experience is representative of causation in general, it follows that all causation is mental, and that panpsychism is true. This kind of argument for panpsychism can be called the argument from (experience of) causation. This chapter offers, first, a history of this argument and arguments closely related to it, and second, an analysis of the argument – is it valid, are its premises in any way defensible, and how does it relate to the other, more popular arguments for panpsychism from philosophy of mind and categorical properties? (shrink)